Domestic Box Office Results for 2022 Week 21 (3-Day May 20 - May 22)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| - | Top Gun: Maverick | PG-13 | Paramount Pictures | $126,707,459 | - | 4,735 | - | $26,760 | $126,707,459 | 1 |
| - | Doctor Strange in the Multiverse of Madness | - | Walt Disney Studios Motion Pictures | $16,069,358 | -50.3% | 3,805 | -729 | $4,223 | $370,443,337 | 4 |
| - | The Bob’s Burgers Movie | PG-13 | 20th Century Studios | $12,416,819 | - | 3,425 | - | $3,625 | $12,416,819 | 1 |
| - | Downton Abbey: A New Era | PG | Focus Features | $5,787,935 | -63.8% | 3,830 | 10 | $1,511 | $28,366,880 | 2 |
| - | The Bad Guys | PG | Universal Pictures | $4,382,790 | -28.6% | 2,944 | -761 | $1,489 | $81,125,690 | 6 |
| - | Everything Everywhere All at Once | - | A24 | $2,463,491 | -21.4% | 1,187 | -389 | $2,075 | $53,114,250 | 10 |
| - | Sonic the Hedgehog 2 | - | Paramount Pictures | $2,454,075 | -40.0% | 2,329 | -614 | $1,054 | $185,073,401 | 8 |
| - | The Lost City | PG-13 | Paramount Pictures | $2,090,685 | 33.8% | 1,027 | -369 | $2,036 | $102,027,685 | 10 |
| - | Men | R | A24 | $1,201,490 | -63.5% | 2,196 | -16 | $547 | $2,255,909 | 2 |
| - | F3: Fun and Frustration | - | Independent | $1,028,000 | - | 400 | - | $2,570 | $1,028,000 | 1 |
| - | Fantastic Beasts: The Secrets of Dumbledore | PG-13 | Warner Bros. | $808,381 | -58.6% | 887 | -1,036 | $911 | $94,695,814 | 7 |
| - | Firestarter | R | Universal Pictures | $285,270 | -85.7% | 999 | -2,414 | $286 | $8,117,135 | 3 |
| - | The Northman | R | Focus Features | $249,660 | -76.2% | 388 | -875 | $643 | $33,788,155 | 6 |
| - | Family Camp | PG | Roadside Attractions | $244,664 | -72.4% | 572 | -485 | $428 | $3,365,090 | 3 |
| - | The Unbearable Weight of Massive Talent | R | Lionsgate | $200,210 | -73.5% | 340 | -481 | $589 | $20,003,619 | 6 |
| - | 2000 Mules | - | D’Souza Media | $163,331 | -78.3% | 340 | -75 | $480 | $1,216,311 | 2 |
| - | Uncharted | PG-13 | Sony Pictures Entertainment (SPE) | $105,538 | -66.9% | 117 | -350 | $902 | $147,869,503 | 15 |
| - | The Roundup | - | Capelight Pictures | $101,319 | -0.9% | 12 | -3 | $8,443 | $271,450 | 2 |
| - | Montana Story | R | Bleecker Street Media | $98,762 | 398.2% | 290 | 266 | $341 | $154,267 | 3 |
| - | The Duke | R | Sony Pictures Classics | $80,377 | -19.8% | 102 | -78 | $788 | $1,337,237 | 6 |
| - | Father Stu | PG-13 | Sony Pictures Entertainment (SPE) | $77,232 | -72.2% | 207 | -318 | $373 | $20,713,341 | 8 |
| - | Morbius | PG-13 | Columbia Pictures | $29,802 | -83.7% | 83 | -124 | $359 | $73,303,849 | 9 |
| - | ¿Y cómo es él? | PG-13 | Lionsgate | $24,393 | -41.9% | 30 | -8 | $813 | $1,441,460 | 6 |
| - | Petite Maman | PG | NEON | $23,591 | -44.4% | 42 | -41 | $562 | $757,720 | 6 |
| - | Freakscene: The Story of Dinosaur Jr. | - | Utopia | $19,074 | - | 2 | - | $9,537 | $19,074 | 1 |
| - | The Batman | - | Warner Bros. | $17,141 | -56.9% | 47 | -29 | $365 | $369,330,759 | 13 |
| - | Pleasure | R | NEON | $16,513 | -46.3% | 33 | -11 | $500 | $91,639 | 3 |
| - | Hit the Road | - | Kino Lorber | $9,982 | 64.5% | 22 | 3 | $454 | $84,735 | 6 |
| - | Spider-Man: No Way Home | PG-13 | Sony Pictures Entertainment (SPE) | $9,435 | -70.6% | 42 | -90 | $225 | $804,757,423 | 24 |
| - | Eiffel | R | Blue Fox Entertainment | $8,920 | -60.6% | 20 | -15 | $446 | $197,700 | 5 |
| - | Rite of the Shaman | - | Purdie Distribution | $7,645 | - | 12 | - | $637 | $7,645 | 1 |
| - | Love in Kilnerry | Other | Independent | $7,561 | -22.3% | 3 | -6 | $2,520 | $61,424 | 8 |
| - | Green Ghost and the Masters of the Stone | PG-13 | Gravitas Ventures | $5,543 | -23.9% | 2 | -1 | $2,772 | $107,828 | 5 |
| - | A Chiara | R | NEON | $4,377 | - | 2 | - | $2,189 | $4,377 | 1 |
| - | The Automat | TV-PG | Independent | $3,496 | 72.6% | 3 | -2 | $1,165 | $227,337 | 15 |
| - | Happening | R | IFC Films | $3,406 | -66.3% | 25 | -46 | $136 | $164,295 | 4 |
| - | Fireheart | TV-PG | Entertainment One | $2,744 | - | 4 | - | $686 | $2,744 | 1 |
| - | Diva (2022 Re-release) | R | Rialto Pictures | $2,280 | -29.0% | 1 | -1 | $2,280 | $47,735 | 4 |
| - | Paap Punyo | - | Swapna Scarecrow | $2,130 | -84.3% | 3 | -88 | $710 | $25,039 | 2 |
| - | Fire in the Mountains | - | Kino Lorber | $1,961 | 9.1% | 5 | 4 | $392 | $4,976 | 2 |
| - | Distant (2022 Re-release) | Other | Big World Pictures | $1,954 | -18.3% | 4 | 3 | $489 | $6,772 | 2 |
| - | Firebird | R | Roadside Attractions | $1,829 | -33.4% | 5 | -5 | $366 | $140,961 | 5 |
| - | The Innocents | Other | IFC Films | $1,560 | -38.1% | 6 | -10 | $260 | $25,361 | 3 |
| - | Jazz Fest: A New Orleans Story | PG-13 | Sony Pictures Entertainment (SPE) | $1,426 | -63.9% | 6 | -5 | $238 | $19,592 | 3 |
| - | Remembering Heaven | - | Purdie Distribution | $1,343 | -73.3% | 3 | -5 | $448 | $38,322 | 4 |
| - | A New Old Play | - | Icarus Films | $986 | -61.3% | 1 | - | $986 | $5,488 | 2 |
| - | The Conversation (2022 Re-release) | PG | Rialto Pictures | $733 | -49.2% | 2 | 1 | $367 | $5,291 | 4 |
| - | Around the World in 80 Days | PG | Viva Pictures | $657 | -90.6% | 5 | -27 | $131 | $41,708 | 3 |
| - | Hold Your Fire | - | IFC Films | $612 | -79.9% | 8 | -6 | $77 | $6,226 | 2 |
| - | Aline | PG-13 | Roadside Attractions | $518 | - | 2 | 2 | $259 | $666,710 | 21 |
| - | We’re All Going to the World’s Fair | Other | Utopia | $438 | -74.6% | 4 | -2 | $110 | $32,471 | 5 |
| - | Mondocane | - | Kino Lorber | $343 | -79.5% | 5 | - | $69 | $2,619 | 2 |
