Domestic Box Office Results for 2021 Week 53 (3-Day Dec 31 - Jan 2)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| - | Spider-Man: No Way Home | PG-13 | Sony Pictures Entertainment (SPE) | $56,023,590 | -33.7% | 4,206 | -130 | $13,320 | $613,600,664 | 3 |
| - | Sing 2 | PG | Universal Pictures | $20,166,520 | -9.7% | 3,892 | - | $5,182 | $88,647,305 | 3 |
| - | The King’s Man | R | 20th Century Studios | $4,565,941 | -22.8% | 3,180 | - | $1,436 | $19,581,455 | 3 |
| - | American Underdog | PG | Lionsgate | $3,907,411 | -33.3% | 2,813 | - | $1,389 | $14,778,035 | 2 |
| - | The Matrix Resurrections | - | Warner Bros. | $3,827,445 | -64.4% | 3,552 | - | $1,078 | $30,911,026 | 3 |
| - | West Side Story | PG-13 | 20th Century Studios | $2,165,827 | -23.9% | 2,690 | -120 | $805 | $29,636,436 | 4 |
| - | Ghostbusters: Afterlife | - | Sony Pictures Entertainment (SPE) | $1,476,591 | 21.3% | 1,645 | -83 | $898 | $123,420,032 | 7 |
| - | Licorice Pizza | R | United Artists Releasing | $1,295,116 | -32.3% | 786 | - | $1,648 | $6,382,891 | 6 |
| - | A Journal for Jordan | PG-13 | Sony Pictures Entertainment (SPE) | $1,211,089 | -45.0% | 2,500 | - | $484 | $4,778,805 | 2 |
| - | Encanto | PG | Walt Disney Studios Motion Pictures | $1,083,545 | -40.3% | 2,800 | - | $387 | $91,386,126 | 7 |
| - | Nightmare Alley | R | Searchlight Pictures | $966,875 | -18.0% | 1,910 | -225 | $506 | $7,580,143 | 3 |
| - | House of Gucci | R | United Artists Releasing | $798,839 | -12.7% | 707 | -200 | $1,130 | $49,023,527 | 7 |
| - | ’83 | TV-14 | Reliance Entertainment | $670,404 | -60.4% | 426 | -60 | $1,574 | $3,525,897 | 2 |
| - | Red Rocket | R | A24 | $336,982 | 94.1% | 385 | 8 | $875 | $709,460 | 4 |
| - | Eternals | PG-13 | Walt Disney Studios Motion Pictures | $104,518 | -24.4% | 175 | -185 | $597 | $164,694,402 | 9 |
| - | Dune | - | Warner Bros. | $56,732 | 11.6% | 111 | - | $511 | $93,444,632 | 11 |
| - | Venom: Let There Be Carnage | PG-13 | Sony Pictures Entertainment (SPE) | $39,168 | 18.9% | 86 | -9 | $455 | $212,638,437 | 14 |
| - | Belfast | PG-13 | Focus Features | $32,165 | 9.7% | 77 | - | $418 | $6,909,025 | 8 |
| - | The French Dispatch | R | Searchlight Pictures | $31,807 | -12.8% | 55 | -15 | $578 | $16,000,416 | 11 |
| - | C’mon C’mon | R | A24 | $31,439 | -34.9% | 26 | -23 | $1,209 | $1,851,138 | 7 |
| - | Parallel Mothers | R | Sony Pictures Classics | $31,130 | -18.6% | 5 | 2 | $6,226 | $116,116 | 2 |
| - | Drive My Car | Other | Janus Films | $25,498 | 21.0% | 14 | -2 | $1,821 | $328,721 | 6 |
| - | Memoria | PG | NEON | $18,122 | 166.6% | 1 | - | $18,122 | $52,656 | 2 |
| - | Resident Evil: Welcome to Raccoon City | R | Screen Gems | $15,156 | 2.8% | 42 | -14 | $361 | $16,937,037 | 7 |
| - | King Richard | PG-13 | Warner Bros. | $13,215 | 9.0% | 50 | - | $264 | $14,730,278 | 7 |
| - | Benedetta | TV-MA | IFC Films | $4,962 | 36.5% | 8 | - | $620 | $336,040 | 5 |
| - | Jockey | R | Sony Pictures Classics | $2,789 | - | 3 | 3 | $930 | $3,858 | 2 |
| - | Flee | PG-13 | NEON | $1,855 | 49.8% | 4 | - | $464 | $56,267 | 5 |
| - | The Scary of Sixty-First | Other | Utopia | $1,518 | 202.4% | 3 | 1 | $506 | $27,316 | 5 |
| - | France | Other | Kino Lorber | $1,401 | 11.5% | 4 | -2 | $350 | $19,733 | 4 |
| - | The Novice | R | IFC Films | $1,222 | 18.2% | 6 | -3 | $204 | $20,520 | 3 |
| - | Julia | PG-13 | Sony Pictures Classics | $1,012 | -54.5% | 5 | -14 | $202 | $376,560 | 8 |
| - | Bad Luck Banging or Loony Porn | Other | Magnolia Pictures | $488 | 30.1% | 4 | -3 | $122 | $57,766 | 7 |
| - | L’Arracheuse de temps | - | Entertainment One | $227 | 89.2% | 2 | - | $114 | $720,080 | 7 |
| - | The Battle at Lake Changjin | Other | CMC Pictures | $108 | -47.1% | 1 | - | $108 | $342,390 | 7 |
