Domestic Box Office Results for 2021 Week 52 (3-Day Dec 24 - Dec 26)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| - | Spider-Man: No Way Home | PG-13 | Sony Pictures Entertainment (SPE) | $84,548,505 | -67.5% | 4,336 | - | $19,499 | $470,413,982 | 2 |
| - | Sing 2 | PG | Universal Pictures | $22,326,230 | - | 3,892 | 3,892 | $5,736 | $37,951,950 | 2 |
| - | The Matrix Resurrections | - | Warner Bros. | $10,749,011 | - | 3,552 | 3,552 | $3,026 | $21,198,376 | 2 |
| - | The King’s Man | R | 20th Century Studios | $5,915,542 | - | 3,180 | 3,180 | $1,860 | $9,582,386 | 2 |
| - | American Underdog | PG | Lionsgate | $5,861,836 | - | 2,813 | - | $2,084 | $5,861,836 | 1 |
| - | West Side Story | PG-13 | 20th Century Studios | $2,847,289 | -22.1% | 2,810 | -10 | $1,013 | $23,974,822 | 3 |
| - | A Journal for Jordan | PG-13 | Sony Pictures Entertainment (SPE) | $2,201,886 | - | 2,500 | - | $881 | $2,201,886 | 1 |
| - | Licorice Pizza | R | United Artists Releasing | $1,911,827 | 2125.7% | 786 | 782 | $2,432 | $3,250,646 | 5 |
| - | Encanto | PG | Walt Disney Studios Motion Pictures | $1,814,171 | -72.0% | 2,800 | -725 | $648 | $88,127,781 | 6 |
| - | ’83 | TV-14 | Reliance Entertainment | $1,692,575 | - | 486 | - | $3,483 | $1,692,575 | 1 |
| - | Ghostbusters: Afterlife | - | Sony Pictures Entertainment (SPE) | $1,216,823 | -64.4% | 1,728 | -1,554 | $704 | $120,442,010 | 6 |
| - | Nightmare Alley | R | Searchlight Pictures | $1,178,912 | -58.1% | 2,135 | -10 | $552 | $5,286,403 | 2 |
| - | House of Gucci | R | United Artists Releasing | $915,339 | -53.9% | 907 | -1,000 | $1,009 | $47,155,205 | 6 |
| - | Red Rocket | R | A24 | $173,583 | 114.9% | 377 | 361 | $460 | $372,478 | 3 |
| - | Eternals | PG-13 | Walt Disney Studios Motion Pictures | $138,310 | -88.5% | 360 | -1,540 | $384 | $164,416,532 | 8 |
| - | Dune | - | Warner Bros. | $50,855 | -79.6% | 111 | -204 | $458 | $93,310,118 | 10 |
| - | C’mon C’mon | R | A24 | $48,277 | 24.1% | 49 | -53 | $985 | $1,819,699 | 6 |
| - | Parallel Mothers | R | Sony Pictures Classics | $38,249 | - | 3 | - | $12,750 | $38,249 | 1 |
| - | The French Dispatch | R | Searchlight Pictures | $36,467 | -67.6% | 70 | -110 | $521 | $15,921,056 | 10 |
| - | Clifford the Big Red Dog | PG | Paramount Pictures | $33,247 | -91.8% | 193 | -1,055 | $172 | $48,871,584 | 8 |
| - | Venom: Let There Be Carnage | PG-13 | Sony Pictures Entertainment (SPE) | $32,953 | -85.4% | 95 | -355 | $347 | $212,559,704 | 13 |
| - | Belfast | PG-13 | Focus Features | $29,320 | -65.4% | 77 | -130 | $381 | $6,836,775 | 7 |
| - | Drive My Car | Other | Janus Films | $21,074 | -51.9% | 16 | -11 | $1,317 | $273,750 | 5 |
| - | Resident Evil: Welcome to Raccoon City | R | Screen Gems | $14,738 | -95.3% | 56 | -663 | $263 | $16,905,032 | 6 |
| - | King Richard | PG-13 | Warner Bros. | $12,126 | -78.3% | 50 | -157 | $243 | $14,701,691 | 6 |
| - | Memoria | PG | NEON | $6,797 | - | 1 | - | $6,797 | $6,797 | 1 |
| - | The Velvet Queen | - | Oscilloscope | $4,276 | - | 2 | 2 | $2,138 | $6,438 | 2 |
| - | Benedetta | TV-MA | IFC Films | $3,636 | -68.7% | 8 | -19 | $455 | $328,135 | 4 |
| - | Nights of Cabiria (2021 Re-release) | Other | Rialto Pictures | $2,915 | -56.3% | 2 | -2 | $1,458 | $14,485 | 2 |
| - | Julia | PG-13 | Sony Pictures Classics | $2,225 | -89.2% | 19 | -238 | $117 | $373,023 | 7 |
| - | Harper | - | Indican Pictures | $1,650 | -83.8% | 3 | -2 | $550 | $18,540 | 2 |
| - | France | Other | Kino Lorber | $1,257 | -51.9% | 6 | 2 | $210 | $16,322 | 3 |
| - | Flee | PG-13 | NEON | $1,238 | -75.8% | 4 | -3 | $310 | $52,328 | 4 |
| - | The Novice | R | IFC Films | $1,034 | -91.6% | 9 | -27 | $115 | $18,485 | 2 |
| - | The Scary of Sixty-First | Other | Utopia | $502 | -95.0% | 2 | -1 | $251 | $23,811 | 4 |
| - | Bad Luck Banging or Loony Porn | Other | Magnolia Pictures | $375 | -93.9% | 7 | -9 | $54 | $56,224 | 6 |
| - | Anita | - | CMC Pictures | $285 | -95.3% | 1 | -4 | $285 | $556,632 | 7 |
| - | The Battle at Lake Changjin | Other | CMC Pictures | $204 | -6.4% | 1 | - | $204 | $342,170 | 6 |
| - | L’Arracheuse de temps | - | Entertainment One | $120 | -99.5% | 2 | -49 | $60 | $719,362 | 6 |
| - | Luzzu | - | Kino Lorber | $81 | -77.5% | 1 | - | $81 | $18,019 | 11 |
