Domestic Box Office Results for 2021 Week 51 (3-Day Dec 17 - Dec 19)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| - | Spider-Man: No Way Home | PG-13 | Sony Pictures Entertainment (SPE) | $260,138,569 | - | 4,336 | - | $59,995 | $260,138,569 | 1 |
| - | Encanto | PG | Walt Disney Studios Motion Pictures | $6,483,152 | -35.1% | 3,525 | -225 | $1,839 | $81,499,759 | 5 |
| - | West Side Story | PG-13 | 20th Century Studios | $3,657,197 | -65.4% | 2,820 | - | $1,297 | $18,223,218 | 2 |
| - | Ghostbusters: Afterlife | - | Sony Pictures Entertainment (SPE) | $3,413,963 | -51.9% | 3,282 | -533 | $1,040 | $117,263,847 | 5 |
| - | Nightmare Alley | R | Searchlight Pictures | $2,811,703 | - | 2,145 | - | $1,311 | $2,811,703 | 1 |
| - | House of Gucci | R | United Artists Releasing | $1,985,602 | -51.7% | 1,907 | -1,500 | $1,041 | $45,017,467 | 5 |
| - | Pushpa: The Rise – Part 1 | - | Independent | $1,320,000 | - | 400 | - | $3,300 | $1,320,000 | 1 |
| - | Eternals | PG-13 | Walt Disney Studios Motion Pictures | $1,206,854 | -61.7% | 1,900 | -1,130 | $635 | $163,613,147 | 7 |
| - | Clifford the Big Red Dog | PG | Paramount Pictures | $404,068 | -69.0% | 1,248 | -1,592 | $324 | $48,590,093 | 7 |
| - | Resident Evil: Welcome to Raccoon City | R | Screen Gems | $316,480 | -80.9% | 719 | -1,853 | $440 | $16,769,470 | 5 |
| - | Dune | - | Warner Bros. | $248,871 | -71.4% | 315 | -633 | $790 | $93,106,125 | 9 |
| - | Venom: Let There Be Carnage | PG-13 | Sony Pictures Entertainment (SPE) | $225,258 | -70.7% | 450 | -553 | $501 | $212,418,307 | 12 |
| - | The French Dispatch | R | Searchlight Pictures | $112,675 | -54.4% | 180 | -130 | $626 | $15,805,835 | 9 |
| - | Licorice Pizza | R | United Artists Releasing | $85,897 | -50.2% | 4 | - | $21,474 | $1,286,904 | 4 |
| - | Belfast | PG-13 | Focus Features | $84,800 | -69.8% | 207 | -612 | $410 | $6,757,060 | 6 |
| - | Red Rocket | R | A24 | $80,760 | -8.4% | 16 | 10 | $5,048 | $198,895 | 2 |
| - | King Richard | PG-13 | Warner Bros. | $55,936 | -89.0% | 207 | -1,195 | $270 | $14,662,837 | 5 |
| - | Drive My Car | Other | Janus Films | $43,834 | -26.5% | 27 | 3 | $1,623 | $217,016 | 4 |
| - | C’mon C’mon | R | A24 | $38,891 | -79.0% | 102 | -467 | $381 | $1,771,422 | 5 |
| - | Schemes in Antiques | - | Well Go USA Entertainment | $36,501 | - | 28 | - | $1,304 | $36,501 | 1 |
| - | National Champions | R | STX Entertainment | $34,818 | -88.4% | 898 | -299 | $39 | $455,492 | 2 |
| - | Aline | PG-13 | Roadside Attractions | $30,803 | -44.1% | 44 | -27 | $700 | $585,732 | 4 |
| - | L’Arracheuse de temps | - | Entertainment One | $23,439 | -55.2% | 51 | -12 | $460 | $718,206 | 5 |
| - | Julia | PG-13 | Sony Pictures Classics | $20,562 | 113.0% | 257 | 212 | $80 | $370,798 | 6 |
| - | Ron’s Gone Wrong | PG | 20th Century Studios | $18,715 | -56.4% | 80 | -130 | $234 | $22,998,307 | 9 |
| - | Spencer | R | NEON | $13,260 | -81.4% | 40 | -188 | $332 | $7,077,453 | 7 |
| - | The Novice | R | IFC Films | $12,301 | - | 36 | - | $342 | $12,301 | 1 |
| - | Benedetta | TV-MA | IFC Films | $11,603 | -77.5% | 27 | -96 | $430 | $317,995 | 3 |
| - | Harper | - | Indican Pictures | $10,170 | - | 5 | - | $2,034 | $10,170 | 1 |
| - | The Scary of Sixty-First | Other | Utopia | $10,135 | 10457.3% | 3 | 2 | $3,378 | $20,412 | 3 |
| - | For the Love of Money | R | Freestyle Releasing | $6,793 | -73.5% | 13 | -66 | $523 | $478,887 | 5 |
| - | Nights of Cabiria (2021 Re-release) | Other | Rialto Pictures | $6,663 | - | 4 | - | $1,666 | $6,663 | 1 |
| - | Bad Luck Banging or Loony Porn | Other | Magnolia Pictures | $6,178 | 23.6% | 16 | 6 | $386 | $52,205 | 5 |
| - | Anita | - | CMC Pictures | $6,100 | -67.5% | 5 | -4 | $1,220 | $553,012 | 6 |
| - | Flee | PG-13 | NEON | $5,114 | -18.9% | 7 | 3 | $731 | $48,001 | 3 |
| - | France | Other | Kino Lorber | $2,615 | -55.0% | 4 | 2 | $654 | $13,302 | 2 |
| - | Une révision | - | Entertainment One | $673 | -48.4% | 1 | -6 | $673 | $160,513 | 7 |
| - | India Sweets and Spices | PG-13 | Bleecker Street Media | $453 | -59.4% | 5 | - | $91 | $288,641 | 5 |
| - | Writing with Fire | Other | Music Box Films | $381 | 53.0% | 2 | - | $191 | $11,964 | 4 |
| - | Luzzu | - | Kino Lorber | $360 | - | 1 | 1 | $360 | $17,938 | 10 |
| - | The Battle at Lake Changjin | Other | CMC Pictures | $218 | -98.1% | 1 | -7 | $218 | $341,787 | 5 |
| - | Shiva Baby | TV-MA | Utopia | $214 | 140.4% | 1 | - | $214 | $158,981 | 28 |
| - | Agnes | - | Magnolia Pictures | $96 | -93.3% | 3 | -2 | $32 | $1,914 | 2 |
