Domestic Box Office Results for 2021 Week 50 (3-Day Dec 10 - Dec 12)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| - | West Side Story | PG-13 | 20th Century Studios | $10,574,618 | - | 2,820 | - | $3,750 | $10,574,618 | 1 |
| - | Encanto | PG | Walt Disney Studios Motion Pictures | $9,985,099 | -24.1% | 3,750 | -230 | $2,663 | $71,905,154 | 4 |
| - | Ghostbusters: Afterlife | - | Sony Pictures Entertainment (SPE) | $7,102,173 | -31.4% | 3,815 | -244 | $1,862 | $112,006,454 | 4 |
| - | House of Gucci | R | United Artists Releasing | $4,112,028 | -41.3% | 3,407 | -64 | $1,207 | $41,083,400 | 4 |
| - | Eternals | PG-13 | Walt Disney Studios Motion Pictures | $3,149,849 | -23.0% | 3,030 | -200 | $1,040 | $161,266,892 | 6 |
| - | Resident Evil: Welcome to Raccoon City | R | Screen Gems | $1,661,194 | -38.2% | 2,572 | -231 | $646 | $15,863,138 | 4 |
| - | Clifford the Big Red Dog | PG | Paramount Pictures | $1,302,231 | -30.9% | 2,840 | -421 | $459 | $47,686,042 | 6 |
| - | Christmas with the Chosen: The Messengers | Other | Fathom Entertainment | $1,240,000 | -70.8% | 1,450 | -250 | $855 | $13,388,000 | 3 |
| - | Dune | - | Warner Bros. | $870,093 | -52.9% | 948 | -269 | $918 | $92,452,021 | 8 |
| - | Venom: Let There Be Carnage | PG-13 | Sony Pictures Entertainment (SPE) | $768,163 | -23.4% | 1,003 | -231 | $766 | $211,971,131 | 11 |
| - | No Time to Die | - | Metro-Goldwyn-Mayer (MGM) | $579,672 | -35.8% | 777 | -565 | $746 | $160,530,850 | 10 |
| - | King Richard | PG-13 | Warner Bros. | $510,306 | -58.4% | 1,402 | -1,252 | $364 | $14,426,682 | 4 |
| - | National Champions | R | STX Entertainment | $301,028 | - | 1,197 | - | $251 | $301,028 | 1 |
| - | True to the Game 3 | R | Faith Media Distribution | $287,319 | -49.9% | 335 | -105 | $858 | $1,038,255 | 2 |
| - | Belfast | PG-13 | Focus Features | $280,605 | -47.4% | 819 | -436 | $343 | $6,494,980 | 5 |
| - | The French Dispatch | R | Searchlight Pictures | $247,142 | -33.7% | 310 | -115 | $797 | $15,564,909 | 8 |
| - | C’mon C’mon | R | A24 | $185,222 | -59.9% | 569 | 4 | $326 | $1,612,482 | 4 |
| - | Licorice Pizza | R | United Artists Releasing | $172,495 | -28.6% | 4 | - | $43,124 | $1,101,683 | 3 |
| - | Red Rocket | R | A24 | $88,195 | - | 6 | - | $14,699 | $88,195 | 1 |
| - | Spencer | R | NEON | $71,245 | -43.8% | 228 | -75 | $312 | $7,018,508 | 6 |
| - | Drive My Car | Other | Janus Films | $59,635 | 114.5% | 24 | 20 | $2,485 | $135,456 | 3 |
| - | Aline | PG-13 | Roadside Attractions | $55,102 | -46.3% | 71 | -1 | $776 | $506,103 | 3 |
| - | L’Arracheuse de temps | - | Entertainment One | $52,330 | -39.2% | 63 | -9 | $831 | $660,559 | 4 |
| - | Benedetta | TV-MA | IFC Films | $51,608 | -62.3% | 123 | -78 | $420 | $270,491 | 2 |
| - | Ron’s Gone Wrong | PG | 20th Century Studios | $42,935 | -58.9% | 210 | -100 | $204 | $22,962,204 | 8 |
| - | Tadap | - | FIP | $29,159 | -48.5% | 50 | -13 | $583 | $115,332 | 2 |
| - | For the Love of Money | R | Freestyle Releasing | $25,645 | -59.7% | 79 | -167 | $325 | $465,975 | 4 |
| - | Antlers | R | Searchlight Pictures | $20,538 | -52.8% | 145 | -35 | $142 | $10,612,386 | 7 |
| - | Anita | - | CMC Pictures | $18,773 | -35.4% | 9 | -1 | $2,086 | $535,596 | 5 |
| - | My Hero Academia: World Heroes’ Mission | PG-13 | FUNimation Entertainment | $16,409 | -38.6% | 36 | -8 | $456 | $12,265,393 | 7 |
| - | Wolf | R | Focus Features | $15,160 | -81.7% | 206 | -102 | $74 | $137,730 | 2 |
| - | The Addams Family 2 | PG | United Artists Releasing | $14,965 | -42.8% | 46 | -61 | $325 | $56,486,856 | 11 |
| - | The Battle at Lake Changjin | Other | CMC Pictures | $11,476 | -63.5% | 8 | -3 | $1,435 | $333,214 | 4 |
| - | Julia | PG-13 | Sony Pictures Classics | $9,655 | -70.2% | 45 | -71 | $215 | $343,110 | 5 |
| - | Flee | PG-13 | NEON | $6,306 | -74.6% | 4 | - | $1,577 | $38,106 | 2 |
| - | Halloween Kills | - | Universal Pictures | $6,230 | -47.4% | 120 | -30 | $52 | $91,999,455 | 9 |
| - | France | Other | Kino Lorber | $5,811 | - | 2 | - | $2,906 | $5,811 | 1 |
| - | Bad Luck Banging or Loony Porn | Other | Magnolia Pictures | $4,998 | 2.7% | 10 | 3 | $500 | $41,185 | 4 |
| - | Agnes | - | Magnolia Pictures | $1,433 | - | 5 | - | $287 | $1,433 | 1 |
| - | Une révision | - | Entertainment One | $1,304 | -32.3% | 7 | - | $186 | $158,311 | 6 |
| - | India Sweets and Spices | PG-13 | Bleecker Street Media | $1,115 | -84.0% | 5 | -25 | $223 | $287,814 | 4 |
| - | Kurt Vonnegut: Unstuck in Time | Other | IFC Films | $402 | -90.8% | 4 | -10 | $101 | $60,038 | 4 |
| - | Writing with Fire | Other | Music Box Films | $249 | -92.8% | 2 | -6 | $125 | $10,023 | 3 |
| - | The Scary of Sixty-First | Other | Utopia | $96 | -98.8% | 1 | - | $96 | $10,066 | 2 |
| - | Shiva Baby | TV-MA | Utopia | $89 | 107.0% | 1 | - | $89 | $158,767 | 27 |
