Domestic Box Office Results for 2021 Week 45 (3-Day Nov 5 - Nov 7)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| - | Eternals | PG-13 | Walt Disney Studios Motion Pictures | $71,297,219 | - | 4,090 | - | $17,432 | $71,297,219 | 1 |
| - | Dune | - | Warner Bros. | $7,790,194 | -49.5% | 3,546 | -579 | $2,197 | $70,345,124 | 3 |
| - | No Time to Die | - | Metro-Goldwyn-Mayer (MGM) | $6,038,799 | -22.1% | 3,007 | -500 | $2,008 | $143,010,207 | 5 |
| - | Venom: Let There Be Carnage | PG-13 | Sony Pictures Entertainment (SPE) | $4,465,015 | -22.4% | 2,640 | -638 | $1,691 | $197,007,650 | 6 |
| - | Ron’s Gone Wrong | PG | 20th Century Studios | $3,573,638 | -4.6% | 2,650 | -910 | $1,349 | $17,550,963 | 3 |
| - | The French Dispatch | R | Searchlight Pictures | $2,582,949 | -0.7% | 1,205 | 417 | $2,144 | $8,452,021 | 3 |
| - | Halloween Kills | - | Universal Pictures | $2,334,460 | -73.3% | 3,098 | -518 | $754 | $89,699,535 | 4 |
| - | Spencer | R | NEON | $2,104,767 | - | 996 | - | $2,113 | $2,104,767 | 1 |
| - | Antlers | R | Searchlight Pictures | $1,971,250 | -53.8% | 2,800 | - | $704 | $7,577,158 | 2 |
| - | Last Night in Soho | - | Focus Features | $1,801,875 | -56.9% | 3,016 | - | $597 | $7,640,510 | 2 |
| - | My Hero Academia: World Heroes’ Mission | PG-13 | FUNimation Entertainment | $1,702,395 | -72.8% | 1,462 | -123 | $1,164 | $9,915,772 | 2 |
| - | Sooryavanshi | TV-14 | Reliance Entertainment | $1,443,475 | - | 491 | - | $2,940 | $1,443,475 | 1 |
| - | The Addams Family 2 | PG | United Artists Releasing | $1,431,977 | -53.5% | 1,807 | -950 | $792 | $54,934,210 | 6 |
| - | Shang-Chi and the Legend of the Ten Rings | PG-13 | Walt Disney Studios Motion Pictures | $613,436 | -43.1% | 440 | -675 | $1,394 | $223,846,343 | 10 |
| - | The Last Duel | - | 20th Century Studios | $134,413 | -75.7% | 220 | -730 | $611 | $10,512,289 | 4 |
| - | Free Guy | - | 20th Century Studios | $73,982 | 0.7% | 95 | -90 | $779 | $121,498,751 | 13 |
| - | The Rescue | PG | Greenwich Entertainment | $44,800 | -12.0% | 56 | -45 | $800 | $991,434 | 5 |
| - | The Souvenir: Part II | R | A24 | $40,794 | 54.0% | 15 | 12 | $2,720 | $73,244 | 2 |
| - | Une révision | - | Entertainment One | $35,742 | - | 51 | - | $701 | $35,742 | 1 |
| - | A Mouthful of Air | R | Stage 6 Films | $34,674 | -73.5% | 723 | -93 | $48 | $247,507 | 2 |
| - | Jungle Cruise | PG-13 | Walt Disney Studios Motion Pictures | $32,370 | 14.1% | 75 | -25 | $432 | $116,944,343 | 15 |
| - | Dear Evan Hansen | PG-13 | Universal Pictures | $30,050 | 2.6% | 220 | -72 | $137 | $14,948,070 | 7 |
| - | Christmas vs. The Walters | PG-13 | Independent | $27,986 | - | 80 | - | $350 | $27,986 | 1 |
| - | Candyman | R | Universal Pictures | $23,250 | -67.4% | 123 | -536 | $189 | $61,181,560 | 11 |
| - | The Beta Test | Other | IFC Films | $17,841 | - | 25 | - | $714 | $17,841 | 1 |
| - | Mass | PG-13 | Bleecker Street Media | $5,417 | -68.7% | 37 | -22 | $146 | $136,774 | 5 |
| - | Becoming Cousteau | PG-13 | Picturehouse | $4,346 | -82.9% | 15 | -137 | $290 | $230,492 | 3 |
| - | Cicada | Other | Strand Releasing | $3,775 | 21.7% | 4 | 3 | $944 | $8,518 | 2 |
| - | Bergman Island | R | IFC Films | $3,572 | -36.4% | 9 | -7 | $397 | $140,117 | 4 |
| - | Only the Animals | - | Cohen Media Group | $3,434 | 1.3% | 6 | 1 | $572 | $9,138 | 2 |
| - | Love It Was Not | - | Greenwich Entertainment | $1,995 | - | 3 | - | $665 | $1,995 | 1 |
| - | I’m Your Man | R | Bleecker Street Media | $1,983 | -26.6% | 3 | -10 | $661 | $267,351 | 7 |
| - | Wife of a Spy | - | Kino Lorber | $1,617 | 183.7% | 3 | 1 | $539 | $61,677 | 8 |
| - | Luzzu | - | Kino Lorber | $1,233 | 52.8% | 3 | -1 | $411 | $14,989 | 4 |
| - | Tango Shalom | PG-13 | Vision Films | $1,202 | -9.4% | 3 | -1 | $401 | $102,651 | 10 |
| - | Breathless (2021 Re-release) | TV-14 | Rialto Pictures | $1,093 | 747.3% | 2 | 1 | $547 | $37,808 | 6 |
| - | Golden Voices | - | Music Box Films | $1,028 | -55.5% | 6 | -2 | $171 | $27,613 | 5 |
| - | Minyan | Other | Strand Releasing | $812 | -62.0% | 2 | -1 | $406 | $11,451 | 3 |
| - | The Lost Leonardo | PG-13 | Sony Pictures Classics | $489 | 41.7% | 3 | - | $163 | $441,188 | 13 |
| - | The Laws of the Universe: The Age of Elohim | PG | Freestyle Releasing | $465 | -80.4% | 1 | -6 | $465 | $14,135 | 3 |
| - | Dear Rider: The Jake Burton Story | R | Greenwich Entertainment | $322 | - | 2 | - | $161 | $322 | 1 |
| - | Shiva Baby | TV-MA | Utopia | $156 | 218.4% | 2 | 1 | $78 | $158,428 | 24 |
