Domestic Box Office Results for 2021 Week 20 (3-Day May 14 - May 16)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| - | Spiral | Other | Lionsgate | $8,750,034 | - | 2,811 | - | $3,113 | $8,750,034 | 1 |
| - | Wrath of Man | R | United Artists Releasing | $3,702,485 | -55.4% | 3,007 | 132 | $1,231 | $14,562,718 | 2 |
| - | Those Who Wish Me Dead | R | Warner Bros. | $2,831,382 | - | 3,188 | - | $888 | $2,831,382 | 1 |
| - | Demon Slayer: Kimetsu no Yaiba – The Movie: Mugen Train | R | FUNimation Entertainment | $1,956,761 | -29.5% | 1,914 | -173 | $1,022 | $42,716,318 | 4 |
| - | Raya and the Last Dragon | PG | Walt Disney Studios Motion Pictures | $1,701,516 | -11.4% | 2,285 | -30 | $745 | $46,107,330 | 11 |
| - | Godzilla vs. Kong | PG-13 | Warner Bros. | $1,520,403 | -23.5% | 2,484 | -221 | $612 | $94,166,804 | 8 |
| - | Mortal Kombat | - | Warner Bros. | $1,328,814 | -44.8% | 2,465 | -508 | $539 | $35,363,255 | 4 |
| - | Finding You | PG | Roadside Attractions | $920,476 | - | 1,312 | - | $702 | $920,476 | 1 |
| - | Profile | R | Focus Features | $730,290 | - | 2,033 | - | $359 | $730,290 | 1 |
| - | Here Today | PG-13 | Stage 6 Films | $535,454 | -48.6% | 1,200 | - | $446 | $1,914,276 | 2 |
| - | Nobody | R | Universal Pictures | $379,945 | -52.6% | 1,553 | -378 | $245 | $25,280,970 | 8 |
| - | The Unholy | PG-13 | Screen Gems | $372,043 | -48.1% | 859 | -531 | $433 | $14,784,060 | 7 |
| - | Tom & Jerry | PG | Warner Bros. | $345,656 | -21.5% | 1,657 | -174 | $209 | $45,066,540 | 12 |
| - | Separation | R | Open Road Films | $331,391 | -68.7% | 1,153 | -758 | $287 | $4,067,854 | 3 |
| - | Top Gun (2021 Re-release) | - | Paramount Pictures | $214,654 | - | 153 | - | $1,403 | $214,654 | 1 |
| - | The Croods: A New Age | PG | Universal Pictures | $175,190 | -2.5% | 1,097 | -103 | $160 | $58,023,700 | 26 |
| - | Four Good Days | R | Vertical Entertainment | $69,946 | -68.9% | 326 | -163 | $215 | $772,669 | 3 |
| - | The Girl Who Believes in Miracles | PG | Atlas Distribution Company | $66,750 | -52.8% | 417 | -191 | $160 | $3,055,175 | 7 |
| - | The Water Man | PG | RLJE Films | $59,829 | -67.0% | 240 | -71 | $249 | $240,875 | 2 |
| - | The Courier | PG-13 | Roadside Attractions | $50,716 | -47.9% | 137 | -143 | $370 | $6,474,667 | 9 |
| - | The Djinn | R | IFC Films | $50,312 | - | 41 | - | $1,227 | $50,312 | 1 |
| - | Minari | PG-13 | A24 | $45,088 | -35.6% | 218 | -144 | $207 | $3,047,650 | 14 |
| - | Together Together | R | Bleecker Street Media | $38,671 | -73.2% | 165 | -284 | $234 | $1,366,260 | 4 |
| - | The Killing of Two Lovers | R | NEON | $25,378 | - | 34 | - | $746 | $25,378 | 1 |
| - | The Truffle Hunters | PG-13 | Sony Pictures Classics | $21,773 | -48.7% | 66 | -27 | $330 | $245,422 | 6 |
| - | Walking with Herb | PG | Fathom Entertainment | $16,974 | -75.5% | 236 | -271 | $72 | $120,226 | 2 |
| - | The Father | PG-13 | Sony Pictures Classics | $16,929 | -72.1% | 75 | -149 | $226 | $2,010,550 | 10 |
| - | Limbo | R | Focus Features | $16,490 | -72.2% | 71 | -142 | $232 | $217,195 | 3 |
| - | Riders of Justice | Other | Magnolia Pictures | $15,441 | - | 17 | - | $908 | $15,441 | 1 |
| - | The War with Grandpa | PG | 101 Studios | $13,239 | -59.6% | 70 | -38 | $189 | $21,242,277 | 32 |
| - | Mission Stories | - | Excel Entertainment | $12,705 | -47.9% | 43 | -1 | $295 | $54,970 | 2 |
| - | My Love | - | CMC Pictures | $11,493 | -61.0% | 18 | -7 | $639 | $62,817 | 2 |
| - | Cliff Walkers | - | CMC Pictures | $10,542 | -63.2% | 19 | -31 | $555 | $130,648 | 3 |
| - | The Paper Tigers | PG-13 | Well Go USA Entertainment | $9,679 | -79.2% | 30 | -35 | $323 | $76,139 | 2 |
| - | Wrong Turn | R | Saban Films | $9,520 | -45.0% | 3 | -7 | $3,173 | $1,213,800 | 17 |
| - | The Resort | - | Vertical Entertainment | $9,323 | -82.6% | 19 | -71 | $491 | $179,393 | 3 |
| - | The Human Factor | PG-13 | Sony Pictures Classics | $6,684 | -57.0% | 55 | -35 | $122 | $31,855 | 2 |
| - | Gunda | G | NEON | $6,154 | -28.1% | 35 | 20 | $176 | $54,254 | 5 |
| - | French Exit | R | Sony Pictures Classics | $5,967 | -53.4% | 16 | -9 | $373 | $686,622 | 7 |
| - | Ghost Master | - | Indican Pictures | $4,212 | - | 2 | - | $2,106 | $4,212 | 1 |
| - | The Swimming Pool (2021 Re-release) | Other | Rialto Pictures | $3,867 | - | 1 | - | $3,867 | $3,867 | 1 |
| - | About Endlessness | - | Magnolia Pictures | $3,584 | -30.6% | 12 | -1 | $299 | $28,678 | 3 |
| - | Mainstream | R | IFC Films | $3,338 | -83.1% | 22 | -54 | $152 | $30,022 | 2 |
| - | There Is No Evil | - | Kino Lorber | $3,242 | - | 7 | - | $463 | $3,242 | 1 |
| - | Shiva Baby | TV-MA | Utopia | $2,998 | -52.6% | 6 | -7 | $500 | $105,448 | 7 |
| - | The Perfect Candidate | - | Music Box Films | $2,795 | - | 5 | - | $559 | $2,795 | 1 |
| - | State Funeral | - | MUBI | $1,542 | -59.5% | 2 | - | $771 | $8,402 | 2 |
| - | Psycho Goreman | TV-14 | RLJE Films | $1,256 | 9.6% | 1 | - | $1,256 | $92,684 | 8 |
| - | Six Minutes to Midnight | PG-13 | IFC Films | $640 | -51.5% | 5 | -4 | $128 | $131,871 | 8 |
| - | Endless Rain | - | Sony Pictures Entertainment (SPE) | $313 | -81.0% | 1 | -13 | $313 | $7,021 | 3 |
