Domestic Box Office Results for 2021 Week 17 (3-Day Apr 23 - Apr 25)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| - | Mortal Kombat | - | Warner Bros. | $23,302,503 | - | 3,073 | - | $7,583 | $23,302,503 | 1 |
| - | Demon Slayer: Kimetsu no Yaiba – The Movie: Mugen Train | R | FUNimation Entertainment | $21,234,994 | - | 1,614 | - | $13,157 | $21,234,994 | 1 |
| - | Godzilla vs. Kong | PG-13 | Warner Bros. | $4,290,232 | -45.3% | 2,856 | -145 | $1,502 | $86,666,076 | 5 |
| - | Nobody | R | Universal Pictures | $1,742,165 | -30.3% | 2,252 | -153 | $774 | $21,553,885 | 5 |
| - | Raya and the Last Dragon | PG | Walt Disney Studios Motion Pictures | $1,741,058 | -9.4% | 1,819 | -126 | $957 | $39,905,227 | 8 |
| - | The Unholy | PG-13 | Screen Gems | $1,463,664 | -28.6% | 1,835 | -222 | $798 | $11,608,793 | 4 |
| - | Tom & Jerry | PG | Warner Bros. | $720,522 | -35.2% | 1,930 | -98 | $373 | $43,542,625 | 9 |
| - | Together Together | R | Bleecker Street Media | $532,773 | - | 665 | - | $801 | $532,773 | 1 |
| - | The Girl Who Believes in Miracles | PG | Atlas Distribution Company | $350,000 | -37.1% | 941 | -71 | $372 | $2,492,225 | 4 |
| - | The Courier | PG-13 | Roadside Attractions | $294,178 | -33.2% | 714 | -209 | $412 | $5,971,835 | 6 |
| - | In the Earth | R | NEON | $219,609 | -56.6% | 571 | 24 | $385 | $910,274 | 2 |
| - | The Croods: A New Age | PG | Universal Pictures | $202,322 | -33.6% | 1,156 | -13 | $175 | $57,350,945 | 23 |
| - | Voyagers | PG-13 | Lionsgate | $170,205 | -78.2% | 1,278 | -718 | $133 | $2,956,741 | 3 |
| - | Minari | PG-13 | A24 | $142,688 | -2.2% | 704 | -41 | $203 | $2,717,017 | 11 |
| - | Chaos Walking | PG-13 | Lionsgate | $107,218 | -48.9% | 1,071 | -171 | $100 | $13,153,403 | 8 |
| - | The Father | PG-13 | Sony Pictures Classics | $80,206 | -42.6% | 575 | -114 | $139 | $1,663,229 | 7 |
| - | 2021 Oscar Nominated Short Films: Live Action | - | Magnolia Pictures | $76,625 | 43.5% | 184 | 71 | $416 | $418,694 | 4 |
| - | The Marksman | PG-13 | Open Road Films | $70,205 | -56.8% | 222 | -109 | $316 | $15,546,779 | 15 |
| - | Promising Young Woman | R | Focus Features | $56,945 | -43.0% | 744 | 108 | $77 | $6,436,740 | 18 |
| - | Wonder Woman 1984 | PG-13 | Warner Bros. | $50,294 | -46.3% | 952 | - | $53 | $46,436,755 | 18 |
| - | French Exit | R | Sony Pictures Classics | $38,612 | -57.1% | 130 | -159 | $297 | $621,947 | 4 |
| - | SAS: Red Notice | R | Vertical Entertainment | $37,000 | -53.0% | 151 | -38 | $245 | $146,329 | 2 |
| - | Wrong Turn | R | Saban Films | $34,415 | -29.1% | 47 | -16 | $732 | $1,138,235 | 14 |
| - | Judas and the Black Messiah | R | Warner Bros. | $32,293 | -43.7% | 714 | -69 | $45 | $5,416,063 | 11 |
| - | The Truffle Hunters | PG-13 | Sony Pictures Classics | $30,082 | 36.2% | 39 | 9 | $771 | $79,394 | 3 |
| - | The Little Things | R | Warner Bros. | $28,065 | -4.3% | 136 | - | $206 | $15,226,613 | 13 |
| - | The War with Grandpa | PG | 101 Studios | $26,055 | -6.6% | 195 | -20 | $134 | $21,174,015 | 29 |
| - | Monster Hunter | PG-13 | Screen Gems | $22,232 | -0.1% | 28 | -15 | $794 | $15,127,022 | 19 |
| - | Held | - | Magnolia Pictures | $13,836 | -62.8% | 121 | - | $114 | $114,214 | 3 |
| - | Shiva Baby | TV-MA | Utopia | $9,819 | -45.2% | 27 | - | $364 | $74,081 | 4 |
| - | Gunda | G | NEON | $7,851 | 56.3% | 10 | 5 | $785 | $15,631 | 2 |
| - | News of the World | PG-13 | Universal Pictures | $7,670 | -70.6% | 92 | -51 | $83 | $12,665,020 | 18 |
| - | Dutch | R | Faith Media Distribution | $5,706 | -47.3% | 5 | -5 | $1,141 | $390,087 | 7 |
| - | Monday | R | IFC Films | $4,687 | -75.0% | 35 | -19 | $134 | $28,065 | 2 |
| - | Six Minutes to Midnight | PG-13 | IFC Films | $4,193 | -50.3% | 19 | -10 | $221 | $123,248 | 5 |
| - | Lamb of God: The Concert Film | - | Excel Entertainment | $1,065 | -82.7% | 13 | -17 | $82 | $740,921 | 7 |
| - | Long Weekend | R | Stage 6 Films | $1,026 | -49.4% | 5 | -9 | $205 | $529,464 | 7 |
| - | The Boonies | - | Indican Pictures | $760 | -48.0% | 1 | -1 | $760 | $5,089 | 4 |
| - | Bill Traylor: Chasing Ghosts | - | Kino Lorber | $755 | -54.7% | 2 | - | $378 | $3,527 | 2 |
| - | Moffie | Other | IFC Films | $633 | -82.9% | 5 | -25 | $127 | $23,781 | 3 |
| - | Blood Brothers: Civil War | - | Indican Pictures | $540 | -55.1% | 1 | - | $540 | $4,456 | 3 |
| - | Slalom | Other | Kino Lorber | $203 | -74.1% | 2 | -1 | $102 | $2,692 | 3 |
